Plrg1^tm2Jcbr
Targeted Allele Detail

Summary

• Symbol: Plrg1^tm2Jcbr
• Name: pleiotropic regulator 1; targeted mutation 2, Jens C Bruning
• MGI ID: MGI:3848231
• Synonyms: PLRG1^FL, PLRG1^flox
• Gene: Plrg1 Location: Chr3:82962845-82979598 bp, + strand Genetic Position: Chr3, 36.99 cM
• Alliance: Plrg1^tm2Jcbr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:149153
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An frt flanked neo cassette with a 5' loxP site was inserted upstream of exon 3 and an additional loxP site was inserted downstream of exon 3. The neo cassette was removed by frt mediated recombination. (J:149153)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plrg1 Mutation: 17 strains or lines available

References

• Original: J:149153 Kleinridders A, et al., PLRG1 is an essential regulator of cell proliferation and apoptosis during vertebrate development and tissue homeostasis. Mol Cell Biol. 2009 Jun;29(11):3173-85
• All: 1 reference(s)