Abca1^m4620Dajl
Chemically induced Allele Detail

Summary

• Symbol: Abca1^m4620Dajl
• Name: ATP-binding cassette, sub-family A member 1; mutation 4620 David J Lloyd
• MGI ID: MGI:3848340
• Synonyms: Abca1^m, Abca1^S1748L
• Gene: Abca1 Location: Chr4:53030787-53159895 bp, - strand Genetic Position: Chr4, 28.57 cM, cytoband A5-B3
• Alliance: Abca1^m4620Dajl page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Nucleotide substitutions
• Mutation details: ENU mutagenesis produced a pedigree line 4620 with a nucleotide substitution within exon 10 that results in an amino acid substitution of leucine for serine at position 1748 (S1748L). (J:149088)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Abca1 Mutation: 90 strains or lines available

References

• Original: J:149088 Juan T, et al., Identification of three loci affecting HDL-cholesterol levels in a screen for chemically induced recessive mutations in mice. J Lipid Res. 2009 Mar;50(3):534-45
• All: 1 reference(s)