Ampd2^m4521Dajl
Chemically induced Allele Detail

Summary

• Symbol: Ampd2^m4521Dajl
• Name: adenosine monophosphate deaminase 2; mutation 4521 David J Lloyd
• MGI ID: MGI:3848348
• Synonyms: Ampd2^m, B6^m
• Gene: Ampd2 Location: Chr3:107981378-107993967 bp, - strand Genetic Position: Chr3, 46.83 cM
• Alliance: Ampd2^m4521Dajl page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a G to T transversion that results in the amino acid substitution of alanine to serine at position 341 (A341S). Western blot analysis confirmed the absence of protein expression in the liver of homozygotes and partial loss in the liver of heterozygotes. (J:223083)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ampd2 Mutation: 45 strains or lines available

References

• Original: J:149088 Juan T, et al., Identification of three loci affecting HDL-cholesterol levels in a screen for chemically induced recessive mutations in mice. J Lipid Res. 2009 Mar;50(3):534-45
• All: 2 reference(s)