Apc^tm1Rsmi
Targeted Allele Detail

Summary

• Symbol: Apc^tm1Rsmi
• Name: APC, WNT signaling pathway regulator; targeted mutation 1, Ron Smits
• MGI ID: MGI:3848479
• Synonyms: Apc^15lox, Apc^16lox, Apc^ex15lox, Apc^tm1Ecrm
• Gene: Apc Location: Chr18:34353977-34455605 bp, + strand Genetic Position: Chr18, 18.53 cM
• Alliance: Apc^tm1Rsmi page

Skeletogenesis is severely impaired in Apc^tm1Rsmi/Apc^tm1Rsmi Tg(Col2a1-cre)1Rsjo/0 mice

Show the 6 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:149225
• Parent Cell Line: IB10/E14IB10 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted upstream of exon 16 (formerly 15) and an additional loxP site was inserted downstream of exon 16. Cre mediated recombination removed the neo cassette leaving exon 16 floxed. (J:149225)

Disease models

Expression

In Structures Affected by this Mutation:

16 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Apc^tm1Rsmi

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Apc Mutation: 158 strains or lines available

References

• Original: J:149225 Miclea RL, et al., Adenomatous polyposis coli-mediated control of beta-catenin is essential for both chondrogenic and osteogenic differentiation of skeletal precursors. BMC Dev Biol. 2009;9:26
• All: 21 reference(s)