Apc^tm1.1Rsmi
Targeted Allele Detail

Summary

• Symbol: Apc^tm1.1Rsmi
• Name: APC, WNT signaling pathway regulator; targeted mutation 1.1, Ron Smits
• MGI ID: MGI:3848480
• Synonyms: Apc^delta15, Apc^tm1.1Ecrm
• Gene: Apc Location: Chr18:34353977-34455605 bp, + strand Genetic Position: Chr18, 18.53 cM
• Alliance: Apc^tm1.1Rsmi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:149225
• Parent Cell Line: IB10/E14IB10 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Cre mediated recombination removed exon 15. (J:149225)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Apc^tm1.1Rsmi

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Apc Mutation: 158 strains or lines available

References

• Original: J:149225 Miclea RL, et al., Adenomatous polyposis coli-mediated control of beta-catenin is essential for both chondrogenic and osteogenic differentiation of skeletal precursors. BMC Dev Biol. 2009;9:26
• All: 3 reference(s)