Btg3^tm1Tya
Targeted Allele Detail

Summary

• Symbol: Btg3^tm1Tya
• Name: BTG anti-proliferation factor 3; targeted mutation 1, Tadashi Yamamoto
• MGI ID: MGI:3848525
• Synonyms: ana^-
• Gene: Btg3 Location: Chr16:78156748-78174069 bp, - strand Genetic Position: Chr16, 45.36 cM
• Alliance: Btg3^tm1Tya page

Enhanced bone formation after BMP implantation in muscles in Btg3^tm1Tya/Btg3^tm1Tya mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:149382
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 1 through exon 2 was replaced with a lacZ cassette and a floxed neo cassette. The absence of protein expression was confirmed by western blot analysis on primary chondrocytes. (J:149382)

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Btg3 Mutation: 19 strains or lines available

References

• Original: J:149382 Yoneda M, et al., Deficiency of antiproliferative family protein Ana correlates with development of lung adenocarcinoma. Cancer Sci. 2009 Feb;100(2):225-32
• All: 2 reference(s)