Mogat2^tm1Far
Targeted Allele Detail

Summary

• Symbol: Mogat2^tm1Far
• Name: monoacylglycerol O-acyltransferase 2; targeted mutation 1, Bob Farese
• MGI ID: MGI:3848538
• Gene: Mogat2 Location: Chr7:98868291-98887818 bp, - strand Genetic Position: Chr7, 54.03 cM
• Alliance: Mogat2^tm1Far page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:149373
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on intestinal extracts. (J:149373)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mogat2 Mutation: 21 strains or lines available

References

• Original: J:149373 Yen CL, et al., Deficiency of the intestinal enzyme acyl CoA:monoacylglycerol acyltransferase-2 protects mice from metabolic disorders induced by high-fat feeding. Nat Med. 2009 Apr;15(4):442-6
• All: 6 reference(s)