Sema3e^{tm1(cre/ERT2)Arbr}
Targeted Allele Detail

Summary

• Symbol: Sema3e^{tm1(cre/ERT2)Arbr}
• Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E; targeted mutation 1, Silvia Arber
• MGI ID: MGI:3848810
• Synonyms: Sema3e^nlz
• Gene: Sema3e Location: Chr5:14075290-14306703 bp, + strand Genetic Position: Chr5, 5.66 cM
• Alliance: Sema3e^{tm1(cre/ERT2)Arbr} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:149553
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutations: Insertion, Intragenic deletion
• Sema3e^{tm1(cre/ERT2)Arbr} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Sema3e (MGI:1340034)

• Mutation details: The sequence downstream of the translation initiation codon was replaced with a cassette containing cre/ERT2 (ESR1), IRES, lacZ gene with a nuclear localization signal, and neo gene. The absence of transcript expression was confirmed by in situ hydridization on cervical spinal cord sections of P0 mice. (J:149553)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Sema3e (mouse) Summary of all recombinase alleles driven by Sema3e. Alliance mouse Sema3e gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sema3e Mutation: 67 strains or lines available

References

• Original: J:149553 Pecho-Vrieseling E, et al., Specificity of sensory-motor connections encoded by Sema3e-Plxnd1 recognition. Nature. 2009 Jun 11;459(7248):842-6
• All: 3 reference(s)