Mapt^{tm3(Sema3e)Arbr}
Targeted Allele Detail

Summary

• Symbol: Mapt^{tm3(Sema3e)Arbr}
• Name: microtubule-associated protein tau; targeted mutation 3, Silvia Arber
• MGI ID: MGI:3848811
• Synonyms: Tau^Sema3
• Gene: Mapt Location: Chr11:104122216-104222916 bp, + strand Genetic Position: Chr11, 67.79 cM, cytoband E1
• Alliance: Mapt^{tm3(Sema3e)Arbr} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:149553
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A cassette containing a floxed STOP, Sema3e coding sequence, IRES, lacZ gene with a nuclear localization signal, and neo cassette was inserted into exon 2. Expression of Sema3e is only achieved following cre mediated recombination. (J:149553)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mapt Mutation: 430 strains or lines available

References

• Original: J:149553 Pecho-Vrieseling E, et al., Specificity of sensory-motor connections encoded by Sema3e-Plxnd1 recognition. Nature. 2009 Jun 11;459(7248):842-6
• All: 1 reference(s)