Plxnd1^tm1.1Tmj
Targeted Allele Detail

Summary

• Symbol: Plxnd1^tm1.1Tmj
• Name: plexin D1; targeted mutation 1.1, Thomas M Jessell
• MGI ID: MGI:3848812
• Synonyms: plexinD1^flox, Plxnd1^flox/flox
• Gene: Plxnd1 Location: Chr6:115931772-115971966 bp, - strand Genetic Position: Chr6, 53.72 cM
• Alliance: Plxnd1^tm1.1Tmj page

Increase in extraretinal vascular outgrowth in ischemic Plxnd1^tm1.1Tmj/Plxnd1^tm1Ddg Tg(CAG-cre/Esr1*)1Egwa/0 retinas

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:143763
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An frt flanked neo cassette with a loxP site was inserted upstream of exon 1 and an additional loxP site was inserted downstream of exon 1. Germ line, flp mediated recombination removed the neo cassette leaving exon 1 floxed. (J:143763)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Plxnd1 Mutation: 87 strains or lines available

References

• Original: J:143763 Zhang Y, et al., Tie2Cre-mediated inactivation of plexinD1 results in congenital heart, vascular and skeletal defects. Dev Biol. 2009 Jan 1;325(1):82-93
• All: 29 reference(s)