Them4^tm1Hem
Targeted Allele Detail

Summary

• Symbol: Them4^tm1Hem
• Name: thioesterase superfamily member 4; targeted mutation 1, Brian Hemmings
• MGI ID: MGI:3848835
• Synonyms: CTMP^-
• Gene: Them4 Location: Chr3:94217415-94239847 bp, + strand Genetic Position: Chr3, 40.51 cM, cytoband F2
• Alliance: Them4^tm1Hem page

Elongated mitochondria in Them4^tm1Hem/Them4^tm1Hem liver

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:149552
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Null/knockout, Reporter) Mutation: Insertion Mutation details: A cassette containing an IRES, lacZ gene, and neo gene was inserted into exon 2. The absence of protein expression was confirmed by western blot analysis on liver mitochondria extracts. (J:149552)

Generation of the Them4^tm1Hem allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Them4 Mutation: 17 strains or lines available

References

• Original: J:149552 Parcellier A, et al., The Carboxy-Terminal Modulator Protein (CTMP) regulates mitochondrial dynamics. PLoS One. 2009;4(5):e5471
• All: 2 reference(s)