Gt(ROSA)26Sor^{tm5(Etv4/en,-GFP)Amc}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm5(Etv4/en,-GFP)Amc}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 5, Andrew P McMahon
• MGI ID: MGI:3848910
• Synonyms: R26-EtvEnR
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm5(Etv4/en,-GFP)Amc} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:149478
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129 and C57BL/6 and CBA and Swiss Webster

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm5(Etv4/en,-GFP)Amc} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Etv4 (MGI:99423)

• Mutation details: A fusion of the mouse gene and sequence encoding the drosophila engrailed repressor element preceded by a floxed STOP/neo cassette and followed by an IRES-GFP was inserted into the locus. (J:149478)

Expression

In Mice Carrying this Mutation:	20 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

Notes

ES cell line = YFP3.1, a male ES cell line carrying Tg(CAG-cre/Esr1*)5Amc and is compound heterozgous at Gt(ROSA)26Sor: Gt(ROSA)26Sor^tm1Sor and Gt(ROSA)26Sor^tm1(EYFP)Cos.

References

• Original: J:149478 Mao J, et al., Fgf-dependent Etv4/5 activity is required for posterior restriction of Sonic Hedgehog and promoting outgrowth of the vertebrate limb. Dev Cell. 2009 Apr;16(4):600-6
• All: 4 reference(s)