Tg(Cdh5-cre/ERT2)1Rha
Transgene Detail

Summary

• Symbol: Tg(Cdh5-cre/ERT2)1Rha
• Name: transgene insertion 1, Ralf H Adams
• MGI ID: MGI:3848982
• Synonyms: Cdh5-CreER, Cdh5(PAC)-CreERT2, Tg:VE-cadherin-(PAC)CreERT2, VE-cad::CreER, VeCadCreERT, VE-Cadherin-Cre-ERT, VE-Cadherin(PAC)-CreERT2
• Transgene: Tg(Cdh5-cre/ERT2)1Rha Location: unknown
• Alliance: Tg(Cdh5-cre/ERT2)1Rha page

Reduced inflammation in aortic roots obtained from tamoxifen-treated, high-fat diet fed Apoe^tm1Unc/Apoe^tm1Unc Tg(Cdh5-cre/ERT2)1Rha/0 Nck1^tm1Paw/Nck1^tm1Paw Nck2^tm3Paw/Nck2^tm3Paw mice.

Show the 4 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Cdh5-cre/ERT2)1Rha expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Cdh5

• Mutation details: The tamoxifen-inducible cre/ERT2 sequence was inserted into a PAC (P1 artificial chromosome) containing the VE-cadherin (Cdh5) gene to generate the transgene construct. (J:148902)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Cdh5 (species not specified) Summary of all recombinase alleles driven by Cdh5. Comparative matrix view of recombinase activities

Disease models

Expression

In Mice Carrying this Mutation:

3 assay results

Tumor Data

List all tumor models in MMHCdb carrying Tg(Cdh5-cre/ERT2)1Rha

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available

References

• Original: J:148902 Sorensen I, et al., DLL1-mediated Notch activation regulates endothelial identity in mouse fetal arteries. Blood. 2009 May 28;113(22):5680-8
• All: 589 reference(s)