Fmn1^tm2Made
Targeted Allele Detail

Summary

• Symbol: Fmn1^tm2Made
• Name: formin 1; targeted mutation 2, Markus Dettenhofer
• MGI ID: MGI:3848983
• Synonyms: Fmn1^Pro
• Gene: Fmn1 Location: Chr2:113158081-113547112 bp, + strand Genetic Position: Chr2, 57.3 cM, cytoband C1-qter
• Alliance: Fmn1^tm2Made page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:149484
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neo cassette was inserted into exon 9. This insertion leads to a disruption at the proline-rich FH1 domain. The absence of protein was confirmed by western blot analysis of embryonic fibroblasts extracts. (J:149484)

Expression

In Mice Carrying this Mutation:	39 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fmn1 Mutation: 76 strains or lines available

References

• Original: J:149484 Zhou F, et al., Formin1 disruption confers oligodactylism and alters Bmp signaling. Hum Mol Genet. 2009 Jul 1;18(13):2472-82
• All: 1 reference(s)