Tpcn2^{Gt(YHD437)Byg}
Gene trapped Allele Detail

Summary

• Symbol: Tpcn2^{Gt(YHD437)Byg}
• Name: two pore segment channel 2; gene trap YHD437, BayGenomics
• MGI ID: MGI:3848998
• Synonyms: Tpcn2^YHD437
• Gene: Tpcn2 Location: Chr7:144740261-144837748 bp, - strand Genetic Position: Chr7, 89.02 cM
• Alliance: Tpcn2^{Gt(YHD437)Byg} page

Mutation origin

• Mutant Cell Line: YHD437
• Germline Transmission: Earliest citation of germline transmission: J:149472
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT0Lxf Vector Type: gene trap
• The gene trap vector pGTOLxf, which contains a beta-geo cassette, inserted between exon 1 and 2. (J:149472)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  YHD437	DX935084 ; (MGI Seq Detail)	5' RACE	Chr7:144837588-144837663 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  1 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tpcn2 Mutation: 52 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:149472 Calcraft PJ, et al., NAADP mobilizes calcium from acidic organelles through two-pore channels. Nature. 2009 May 28;459(7246):596-600
• All: 16 reference(s)