Tg(TcraTcrbNY4.1)1Pesa
Transgene Detail

Summary

• Symbol: Tg(TcraTcrbNY4.1)1Pesa
• Name: transgene insertion 1, Pere Santamaria
• MGI ID: MGI:3849006
• Synonyms: 4.1 NOD, 4.1-NOD, 4.1-TCR, NY4.1
• Transgene: Tg(TcraTcrbNY4.1)1Pesa Location: unknown
• Alliance: Tg(TcraTcrbNY4.1)1Pesa page

Transgene origin

• Strain of Origin: (SJL x C57BL/6J)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(TcraTcrbNY4.1)1Pesa expresses 2 genes
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tcra (MGI:98553)
  mouse	Tcrb (MGI:98578)

• Mutation details: Functional VDJ beta (V beta 11 and J beta 2.4) and VJ alpha (V alpha x4.1 and J alpha 33) rearrangements were isolated from the beta cell cytotoxic CD4(+) T cell clone NY4.1. Upstream regulatory sequences together with either TCR-beta or TCR-alpha enhancers, as appropriate, were associated with VDJbeta or VJalpha. The resulting TCR alpha and beta constructs were coinjected and cointegrated into (SJLXC57BL/6J)F2 oocytes. (J:108768)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:108768 Schmidt D, et al., A mechanism for the major histocompatibility complex-linked resistance to autoimmunity. J Exp Med. 1997 Oct 6;186(7):1059-75
• All: 7 reference(s)