Rbm15^{tm1.1(MAL)Dgg}
Targeted Allele Detail

Summary

• Symbol: Rbm15^{tm1.1(MAL)Dgg}
• Name: RNA binding motif protein 15; targeted mutation 1.1, D Gilliland
• MGI ID: MGI:3849068
• Synonyms: Ott^Ott-MAL, Ott^{tm1.1(MAL)Dgg}
• Gene: Rbm15 Location: Chr3:107232737-107240989 bp, - strand Genetic Position: Chr3, 46.83 cM
• Alliance: Rbm15^{tm1.1(MAL)Dgg} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:149622
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

Allele Type: Targeted Mutations: Insertion, Intragenic deletion Mutation details: Germ line, cre mediated recombination removes the floxed neo and STOP cassette. This allele expresses a fusion product associated with the t(1;22)(p13;q13) chromosomal translocation in patients with one twenty-two-megakaryocytic acute leukemia (OTT-MAL). (J:149622)

Generation of the Rbm15^tm1(MAL)Dgg and Rbm15^tm1.1(MAL)Dgg alleles

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rbm15 Mutation: 30 strains or lines available

References

• Original: J:149622 Mercher T, et al., The OTT-MAL fusion oncogene activates RBPJ-mediated transcription and induces acute megakaryoblastic leukemia in a knockin mouse model. J Clin Invest. 2009 Apr;119(4):852-64
• All: 1 reference(s)