Wif1^tm1Dmth
Targeted Allele Detail

Summary

• Symbol: Wif1^tm1Dmth
• Name: Wnt inhibitory factor 1; targeted mutation 1, David M Thomas
• MGI ID: MGI:3849075
• Synonyms: Wif1^lacZ
• Gene: Wif1 Location: Chr10:120869909-120936547 bp, + strand Genetic Position: Chr10, 68.98 cM
• Alliance: Wif1^tm1Dmth page

Wif1^tm1Dmth/Wif1^tm1Dmth mice are susceptible to spontaneous and radiation-induced osteosarcoma

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:149607
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

Allele Type: Targeted (Null/knockout, Reporter) Mutation: Insertion Mutation details: A tau-lacZ cassette and a floxed neo cassette were inserted into the initiation codon via homologous recombination. This insertion created multiple in-frame stop codons. In situ hybridization analysis indicates that lacZ expression recapitulates endogenous gene expression. (J:149607)

Generation of the Wif1^tm1Dmth allele

Expression

In Mice Carrying this Mutation:

13 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wif1 Mutation: 27 strains or lines available

References

• Original: J:149607 Kansara M, et al., Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice. J Clin Invest. 2009 Apr;119(4):837-51
• All: 9 reference(s)