P2ry14^tm1Gbtm
Targeted Allele Detail

Summary

• Symbol: P2ry14^tm1Gbtm
• Name: purinergic receptor P2Y, G-protein coupled, 14; targeted mutation 1, Gary B T Moore
• MGI ID: MGI:3849078
• Synonyms: GPR105 null
• Gene: P2ry14 Location: Chr3:59022044-59060913 bp, - strand Genetic Position: Chr3, 28.96 cM
• Alliance: P2ry14^tm1Gbtm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:149708
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced with a lacZ and neo cassette. The absence of transcript expression was confirmed by RT-PCR on brain, lung, and esophagus extracts. (J:149708)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any P2ry14 Mutation: 31 strains or lines available

References

• Original: J:149708 Bassil AK, et al., UDP-glucose modulates gastric function through P2Y14 receptor-dependent and -independent mechanisms. Am J Physiol Gastrointest Liver Physiol. 2009 Apr;296(4):G923-30
• All: 4 reference(s)