Tg(Foxp3-HBEGF/EGFP)23.2Spar
Transgene Detail
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Symbol: |
Tg(Foxp3-HBEGF/EGFP)23.2Spar |
Name: |
transgene insertion 23.2, Tim Sparwasser |
MGI ID: |
MGI:3849080 |
Synonyms: |
DEREG, Foxp3-IRES-DTR-GFP BAC-Tg, Tg(Foxp3-DTR/EGFP)1Ebe, Tg(Foxp3-DTR/EGFP)23.2Spar |
Transgene: |
Tg(Foxp3-HBEGF/EGFP)23.2Spar Location: unknown
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Alliance: |
Tg(Foxp3-HBEGF/EGFP)23.2Spar page
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Transgene Type: |
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Transgenic (Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(Foxp3-HBEGF/EGFP)23.2Spar expresses
2 genes
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
mouse |
Foxp3 (MGI:1891436) |
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human |
HBEGF (1839) |
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Mutation details: The RP23-267C15 bacterial artificial chromosome (BAC) containing at least ten mouse genes was obtained. This BAC was modified by targeting a simian diphtheria toxin receptor-enhanced green fluorescent protein (DTR-eGFP) fusion protein and an SV40 polyA element into the first exon of the Foxp3 (forkhead box P3) locus: none of the other loci on the BAC were mutated. Two high expressing lines (16.1 and 23.2) were established. Analysis revealed selective DTR-eGFP expression within the CD4+ T cell compartment, with the highest expression within the CD25+ subset.
(J:125295)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 2 strains available
Cell Lines: 0 lines available
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Original: |
J:125295 Lahl K, et al., Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease. J Exp Med. 2007 Jan 22;204(1):57-63 |
All: |
189 reference(s) |
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