Six1^Cwe
Chemically induced Allele Detail

Summary

• Symbol: Six1^Cwe
• Name: sine oculis-related homeobox 1; Catweasel
• MGI ID: MGI:3849082
• Synonyms: ABE4
• Gene: Six1 Location: Chr12:73088601-73093486 bp, - strand Genetic Position: Chr12, 30.34 cM
• Alliance: Six1^Cwe page

Mutation origin

• Strain of Origin: C3HeB/FeJ

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced an A to G transition at position 411 resulting in an amino acid substitution of glycine for glutamic acid at position 135 (E135G). This mutation in the homeobox is predicted to cause destabilisation of DNA binding. (J:149467)
• Inheritance: Dominant

Disease models

Expression

In Mice Carrying this Mutation:	22 assay results
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Six1 Mutation: 19 strains or lines available

References

• Original: J:149467 Bosman EA, et al., Catweasel mice: a novel role for Six1 in sensory patch development and a model for branchio-oto-renal syndrome. Dev Biol. 2009 Apr 15;328(2):285-96
• All: 2 reference(s)