Atoh1^{tm1(cre/ERT2)Mhos}
Targeted Allele Detail

Summary

• Symbol: Atoh1^{tm1(cre/ERT2)Mhos}
• Name: atonal bHLH transcription factor 1; targeted mutation 1, Mikio Hoshino
• MGI ID: MGI:3849084
• Synonyms: Atoh1^CreERn, Atoh1^null
• Gene: Atoh1 Location: Chr6:64706109-64708229 bp, + strand Genetic Position: Chr6, 30.03 cM
• Alliance: Atoh1^{tm1(cre/ERT2)Mhos} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:149533
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inducible, Null/knockout, Recombinase)
• Inducer: tamoxifen
• Mutations: Insertion, Intragenic deletion
• Atoh1^{tm1(cre/ERT2)Mhos} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Atoh1 (MGI:104654)

• Mutation details: The Atoh1 locus was targeted with a vector that replaced the open-reading frame (ORF) of the gene with the sequence encoding cre recombinase fused to a mutated estrogen ligand-binding domain (ERT2), resulting in a null allele. (J:149533)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Atoh1 (mouse) Summary of all recombinase alleles driven by Atoh1. Alliance mouse Atoh1 gene page

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atoh1 Mutation: 37 strains or lines available

References

• Original: J:149533 Fujiyama T, et al., Inhibitory and excitatory subtypes of cochlear nucleus neurons are defined by distinct bHLH transcription factors, Ptf1a and Atoh1. Development. 2009 Jun;136(12):2049-58
• All: 10 reference(s)