Arhgef12^tm1.1Wet
Targeted Allele Detail

Summary

• Symbol: Arhgef12^tm1.1Wet
• Name: Rho guanine nucleotide exchange factor 12; targeted mutation 1.1, Nina Wettschureck
• MGI ID: MGI:3849180
• Synonyms: LARG^fl
• Gene: Arhgef12 Location: Chr9:42875138-43017069 bp, - strand Genetic Position: Chr9, 24.14 cM, cytoband B
• Alliance: Arhgef12^tm1.1Wet page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:149560
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 16-18 of Arhgef12 were flanked with loxP sites with a frt-flanked neomycin cassette inserted for targeting purposes. The neomycin cassette was later deleted by crossing with Flpe transgenic mice. Gene expression was unaffected as determined by western blotting of cortex lysates. Upon expression of cre recombinase, a null allele is created. (J:149560)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arhgef12 Mutation: 89 strains or lines available

References

• Original: J:149560 Herroeder S, et al., Guanine nucleotide-binding proteins of the G12 family shape immune functions by controlling CD4+ T cell adhesiveness and motility. Immunity. 2009 May;30(5):708-20
• All: 4 reference(s)