Tcrd-V5^tm1Slek
Targeted Allele Detail

Summary

• Symbol: Tcrd-V5^tm1Slek
• Name: T cell receptor delta, variable 5; targeted mutation 1, Barry P Sleckman
• MGI ID: MGI:3849286
• Synonyms: Tcralpha/delta^5deltaT
• Gene: Tcrd-V5 Location: unknown Genetic Position: Chr14, Syntenic
• Alliance: Tcrd-V5^tm1Slek page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:149413
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A floxed neomycin cassette replaced 4 kb of genomic sequence that included the V5 gene segment and the intervening sequence that lies between the V5 gene segment and the TEA promoter. Cre-mediated deletion of the neomycin cassette removed the V5 gene segment and brought the TEA promoter into the same genomic position as the V5 gene segment. Correct targeting was confirmed by Southern blotting. (J:149413)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tcrd-V5 Mutation: 0 strains or lines available

References

• Original: J:149413 Huang CY, et al., Developmental stage-specific regulation of TCR-alpha-chain gene assembly by intrinsic features of the TEA promoter. J Immunol. 2007 Jul 1;179(1):449-54
• All: 1 reference(s)