Trim21^tm1Hm
Targeted Allele Detail

Summary

• Symbol: Trim21^tm1Hm
• Name: tripartite motif-containing 21; targeted mutation 1, Herbert Morse III
• MGI ID: MGI:3849316
• Gene: Trim21 Location: Chr7:102207127-102214689 bp, - strand Genetic Position: Chr7, 54.76 cM, cytoband F1
• Alliance: Trim21^tm1Hm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:149298
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3 through 5 were replaced with EGFP and a floxed neo cassette. Cre mediated recombination removed the neo cassette. (J:149298)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Trim21^tm1Hm

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Trim21 Mutation: 26 strains or lines available

References

• Original: J:149298 Yoshimi R, et al., Gene disruption study reveals a nonredundant role for TRIM21/Ro52 in NF-kappaB-dependent cytokine expression in fibroblasts. J Immunol. 2009 Jun 15;182(12):7527-38
• All: 18 reference(s)