Celsr3^tm1Mrc
Targeted Allele Detail

Summary

• Symbol: Celsr3^tm1Mrc
• Name: cadherin, EGF LAG seven-pass G-type receptor 3; targeted mutation 1, Mario R Capecchi
• MGI ID: MGI:3849321
• Synonyms: Celsr3^EGFP
• Gene: Celsr3 Location: Chr9:108703519-108730168 bp, + strand Genetic Position: Chr9, 59.63 cM
• Alliance: Celsr3^tm1Mrc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:149145
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129S1/Sv or 129X1/SvJ or 129S6/SvEvTac or C57BL/6NCr

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 and 2 were replaced with EGFP with a termination codon and a transcription termination sequence. (J:149145, J:149883)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Celsr3 Mutation: 122 strains or lines available

Notes

R1 [(129X1/SvJ x 129S1/Sv)F1-Kitl<+>] or G4 [(129S6/SvEvTac x C57BL/6NCr)F1] ES cells were used (J:149883).

References

• Original: J:149145 Ying G, et al., The protocadherin gene Celsr3 is required for interneuron migration in the mouse forebrain. Mol Cell Biol. 2009 Jun;29(11):3045-61
• All: 5 reference(s)