H2ax^tm2.1Fwa
Targeted Allele Detail

Summary

• Symbol: H2ax^tm2.1Fwa
• Name: H2A.X variant histone; targeted mutation 2.1, Frederick W Alt
• MGI ID: MGI:3849331
• Synonyms: H2afx^flox
• Gene: H2ax Location: Chr9:44246012-44247374 bp, + strand Genetic Position: Chr9, 24.84 cM
• Alliance: H2ax^tm2.1Fwa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:149487
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted 5' of the promoter and a floxed neo cassette was inserted 3' of coding exon. Cre mediated recombination removed the floxed neo leaving the coding region floxed. (J:84909)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying H2ax^tm2.1Fwa

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any H2ax Mutation: 7 strains or lines available

References

• Original: J:149487 Economopoulou M, et al., Histone H2AX is integral to hypoxia-driven neovascularization. Nat Med. 2009 May;15(5):553-8
• All: 10 reference(s)