Tg(CAG-RAB9A)500Repa
Transgene Detail

Summary

• Symbol: Tg(CAG-RAB9A)500Repa
• Name: transgene insertion 500, Richard E Pagano
• MGI ID: MGI:3849445
• Synonyms: Rab9^TG, Rab9TG
• Transgene: Tg(CAG-RAB9A)500Repa Location: unknown
• Alliance: Tg(CAG-RAB9A)500Repa page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F1 x C57BL/6

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(CAG-RAB9A)500Repa expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  RAB9A (9367)

  Rab9	(MGI:1890695)

• Mutation details: A transgenic construct containing a HA-tagged human RAB9A, member RAS oncogene family, gene (RAB9A) under the control of the CAG promoter (CAGGS, chicken beta actin promoter/enhancer coupled with the cytomegalovirus immediate-early enhancer), was injected into fertilized (C57BL/6 X CBA)F1 X C57BL/6 mouse eggs. Founder line 500 was subsequently established. Expression is approximately 30-fold higher than endogenous Rab9 protein in the liver. (J:144240)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:144240 Kaptzan T, et al., Development of a Rab9 transgenic mouse and its ability to increase the lifespan of a murine model of Niemann-Pick type C disease. Am J Pathol. 2009 Jan;174(1):14-20
• All: 1 reference(s)