Mterf2^{Gt(OST453159)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Mterf2^{Gt(OST453159)Lex}
• Name: mitochondrial transcription termination factor 2; gene trap OST453159, Lexicon Genetics
• MGI ID: MGI:3849455
• Synonyms: mTerf2^-
• Gene: Mterf2 Location: Chr10:84955297-84963891 bp, - strand Genetic Position: Chr10, 41.63 cM, cytoband C1
• Alliance: Mterf2^{Gt(OST453159)Lex} page

Mutation origin

• Mutant Cell Line: OST453159
• Germline Transmission: Earliest citation of germline transmission: J:149828
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: A genetrap vector inserted between exons 2 and 3 of the gene locus. Gene inactivation was confirmed by a lack of signal in immunoblot analysis of homozygote heart, kidney, brain, and liver extracts. (J:149828)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST453159	CG665165 ; (MGI Seq Detail)	3' RACE	Chr10:84956325-84956668 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  3 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mterf2 Mutation: 17 strains or lines available

References

• Original: J:149828 Wenz T, et al., mTERF2 regulates oxidative phosphorylation by modulating mtDNA transcription. Cell Metab. 2009 Jun;9(6):499-511
• All: 2 reference(s)