Angptl3^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Angptl3^tm1Lex
• Name: angiopoietin-like 3; targeted mutation 1, Lexicon Pharmaceuticals
• MGI ID: MGI:3849576
• Synonyms: Angptl3^-
• Gene: Angptl3 Location: Chr4:98919191-98926429 bp, + strand Genetic Position: Chr4, 45.6 cM
• Alliance: Angptl3^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:149912
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

Allele Type: Targeted (Null/knockout) Mutation: Intragenic deletion Mutation details: The first 4 exons of the gene were replaced with a lacZ/neomycin cassette. Correct targeting was confirmed by Southern blotting. (J:149912)

Generation of the Angptl3^tm1Lex allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Angptl3 Mutation: 36 strains or lines available

Notes

See also, data as provided by Lexicon Genetics, Inc.

References

• Original: J:149912 Lee EC, et al., Identification of a new functional domain in angiopoietin-like 3 (ANGPTL3) and angiopoietin-like 4 (ANGPTL4) involved in binding and inhibition of lipoprotein lipase (LPL). J Biol Chem. 2009 May 15;284(20):13735-45
• All: 7 reference(s)