Angptl4^tm2Lex
Targeted Allele Detail

Summary

• Symbol: Angptl4^tm2Lex
• Name: angiopoietin-like 4; targeted mutation 2, Lexicon Pharmaceuticals
• MGI ID: MGI:3849577
• Synonyms: Angptl4^E40K, Angptl4^K
• Gene: Angptl4 Location: Chr17:33993874-34000549 bp, - strand Genetic Position: Chr17, 17.98 cM
• Alliance: Angptl4^tm2Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:149912
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

Allele Type: Targeted Mutation: Nucleotide substitutions Mutation details: The codon encoding the glutamic acid at postion 40 was mutated by a G-to-A transition to instead code for lysine (E40K). A floxed neomycin cassette was included for targeting purposes and was subsequently removed by cre recombinase expression in ES cells. Mutant gene expression in homozygote liver and kidney was similar to endogenous levels as determined by RT-PCR analysis. (J:149912)

Generation of the Angptl4^tm2Lex allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Angptl4 Mutation: 34 strains or lines available

References

• Original: J:149912 Lee EC, et al., Identification of a new functional domain in angiopoietin-like 3 (ANGPTL3) and angiopoietin-like 4 (ANGPTL4) involved in binding and inhibition of lipoprotein lipase (LPL). J Biol Chem. 2009 May 15;284(20):13735-45
• All: 1 reference(s)