Tg(Rr141-cre)1Ksec
Transgene Detail

Summary

• Symbol: Tg(Rr141-cre)1Ksec
• Name: transgene insertion 1, Katheryn S E Cheah
• MGI ID: MGI:3849597
• Synonyms: B2-r4-Cre, Tg(Hoxb2-cre)1Ksec
• Transgene: Tg(Rr141-cre)1Ksec Location: unknown
• Alliance: Tg(Rr141-cre)1Ksec page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Rr141-cre)1Ksec expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Hoxb2 (MGI:96183)

• Mutation details: The 3.4 kb transgene construct contained a 1.4 kb genomic fragment containing murine Hoxb2 rhombomere 4 (r4) enhancer Rr141 inserted upstream of the beta-globin promoter to drive expression of cre cDNA with a nuclear localization signal (NLS). Five founder lines were generated. Line 5 showed mosaic expression when crossed to R26R reporter animals, while the remaining 4 recapitulated the Hoxb2-r4 expression pattern as reported previously. Lines 3 and 4 showed higher background staining while line 1 showed stronger cre activity than line 2. Line 1 was used for subsequent analyses. (J:149900)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Hoxb2 (mouse) Summary of all recombinase alleles driven by Hoxb2. Comparative matrix view of recombinase activities Alliance mouse Hoxb2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:149900 Szeto IY, et al., Utility of HoxB2 enhancer-mediated Cre activity for functional studies in the developing inner ear. Genesis. 2009 Jun;47(6):361-5
• All: 5 reference(s)