Gcnt4^tm1Jxm
Targeted Allele Detail

Summary

• Symbol: Gcnt4^tm1Jxm
• Name: glucosaminyl (N-acetyl) transferase 4, core 2 (beta-1,6-N-acetylglucosaminyltransferase); targeted mutation 1, Jamey Marth
• MGI ID: MGI:3849680
• Synonyms: C2GnT3, Gcnt4^F
• Gene: Gcnt4 Location: Chr13:97061197-97087414 bp, + strand Genetic Position: Chr13, 50.66 cM
• Alliance: Gcnt4^tm1Jxm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:149909
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was used to place a floxed neomycin-thymidine kinase expression cassette downstream of the single coding exon, and a loxP site upstream. Transient Cre expression in targeted ES cells excised the neo cassette and left the floxed exon. (J:149909)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gcnt4 Mutation: 30 strains or lines available

References

• Original: J:149909 Stone EL, et al., Glycosyltransferase function in core 2-type protein O glycosylation. Mol Cell Biol. 2009 Jul;29(13):3770-82
• All: 1 reference(s)