Fbxo45^tm1Kei
Targeted Allele Detail

Summary

• Symbol: Fbxo45^tm1Kei
• Name: F-box protein 45; targeted mutation 1, Keiichi I Nakayama
• MGI ID: MGI:3849742
• Gene: Fbxo45 Location: Chr16:32048930-32065843 bp, - strand Genetic Position: Chr16, 22.45 cM
• Alliance: Fbxo45^tm1Kei page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:149890
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 1 kb genomic DNA fragment containing exon 1was replaced with an IRES-lacZ and neo cassette via homologous recombination. Immunoblot analysis confirmed the absence of protein expression in all tissues examined. (J:149890)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fbxo45 Mutation: 13 strains or lines available

References

• Original: J:149890 Saiga T, et al., Fbxo45 forms a novel ubiquitin ligase complex and is required for neuronal development. Mol Cell Biol. 2009 Jul;29(13):3529-43
• All: 1 reference(s)