Actg1^tm1.1Erv
Targeted Allele Detail

Summary

• Symbol: Actg1^tm1.1Erv
• Name: actin, gamma, cytoplasmic 1; targeted mutation 1.1, James M Ervasti
• MGI ID: MGI:3849834
• Gene: Actg1 Location: Chr11:120236513-120239321 bp, - strand Genetic Position: Chr11, 84.07 cM, cytoband E2
• Alliance: Actg1^tm1.1Erv page

Morphology of stereocilia bundles in adult wild-type and Actg1^tm1.1Erv/Actg1^tm1.1Erv mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:150067
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Germ line, cre mediated recombination removed exon 2 and 3. The absence of protein product was confirmed by western blot analysis on cochlear, brain, kidney, and lung extracts. (J:112808, J:150067)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Actg1 Mutation: 23 strains or lines available

References

• Original: J:150067 Belyantseva IA, et al., Gamma-actin is required for cytoskeletal maintenance but not development. Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9703-8
• All: 6 reference(s)