Sox21^tm1.1Ysa
Targeted Allele Detail

Summary

• Symbol: Sox21^tm1.1Ysa
• Name: SRY (sex determining region Y)-box 21; targeted mutation 1.1, Yumiko Saga
• MGI ID: MGI:3849852
• Gene: Sox21 Location: Chr14:118470645-118474442 bp, - strand Genetic Position: Chr14, 61.92 cM
• Alliance: Sox21^tm1.1Ysa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:150086
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding sequence was replaced with an in frame EGFP cDNA and a floxed pgk-neo cassette. Cre mediated recombination then removed the neo cassette. In situ hybridization analysis confirmed the absence of expression in the hair follicles from homozygous mice. (J:150086)

Expression

In Mice Carrying this Mutation:	59 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sox21 Mutation: 12 strains or lines available

References

• Original: J:150086 Kiso M, et al., The disruption of Sox21-mediated hair shaft cuticle differentiation causes cyclic alopecia in mice. Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9292-7
• All: 9 reference(s)