Cebpb^tm1.1Acle
Targeted Allele Detail

Summary

• Symbol: Cebpb^tm1.1Acle
• Name: CCAAT/enhancer binding protein beta; targeted mutation 1.1, Achim Leutz
• MGI ID: MGI:3849861
• Synonyms: c/ebpbeta^L, LIP k.i.
• Gene: Cebpb Location: Chr2:167530835-167532338 bp, + strand Genetic Position: Chr2, 87.58 cM
• Alliance: Cebpb^tm1.1Acle page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:150006
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Dominant negative)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding sequence was replaced with one encoding a truncated and dominant inhibitory isoform followed by a floxed neo cassette. Nucleotides 91 through 550 encoding the long transactivating transcript (LAP*) and N termini are deleted. Only the short repressive transcript is produced. Germ line, cre mediated recombination removed the neo cassette. (J:150006)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cebpb Mutation: 26 strains or lines available

References

• Original: J:150006 Smink JJ, et al., Transcription factor C/EBPbeta isoform ratio regulates osteoclastogenesis through MafB. EMBO J. 2009 Jun 17;28(12):1769-81
• All: 5 reference(s)