Mrgprd^{tm2.1(Hbegf)Mjz}
Targeted Allele Detail

Summary

• Symbol: Mrgprd^{tm2.1(Hbegf)Mjz}
• Name: MAS-related GPR, member D; targeted mutation 2.1, Mark J Zylka
• MGI ID: MGI:3849868
• Synonyms: Mrgprd^DTR, Mrgprd^{tm2.1(DTR)Mjz}
• Gene: Mrgprd Location: Chr7:144868572-144877796 bp, + strand Genetic Position: Chr7, 89.06 cM
• Alliance: Mrgprd^{tm2.1(Hbegf)Mjz} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:149999
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mrgprd^{tm2.1(Hbegf)Mjz} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  Not Specified	Hbegf

• Mutation details: The open reading frame was replaced with a diphtheria toxin receptor gene, an IRES, farnesylated EGFP gene, and self-excising neo cassette. Ablation of Mrgprd+ neurons occurs following treatment with diphtheria toxin. (J:149999)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mrgprd Mutation: 26 strains or lines available

References

• Original: J:149999 Cavanaugh DJ, et al., Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli. Proc Natl Acad Sci U S A. 2009 Jun 2;106(22):9075-80
• All: 5 reference(s)