Mrgprd^tm3(DTA)Mjz
Targeted Allele Detail

Summary

• Symbol: Mrgprd^tm3(DTA)Mjz
• Name: MAS-related GPR, member D; targeted mutation 3, Mark J Zylka
• MGI ID: MGI:3849869
• Synonyms: Mrgprd^DTA
• Gene: Mrgprd Location: Chr7:144868572-144877796 bp, + strand Genetic Position: Chr7, 89.06 cM
• Alliance: Mrgprd^tm3(DTA)Mjz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:149999
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inducible, Inserted expressed sequence, Reporter)
• Inducer: doxycycline/tetracycline
• Mutations: Insertion, Intragenic deletion
• Mutation details: The open reading frame was replaced with a rtTA and IRES-EGFP followed by a tet operator and diphtheria toxin gene. The diphtheria toxin is expressed in a doxycycline-independent manner causing ablation of Mrgprd+ neurons from birth. (J:149999)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mrgprd Mutation: 26 strains or lines available

References

• Original: J:149999 Cavanaugh DJ, et al., Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli. Proc Natl Acad Sci U S A. 2009 Jun 2;106(22):9075-80
• All: 2 reference(s)