Sost^tm1Paz
Targeted Allele Detail

Summary

• Symbol: Sost^tm1Paz
• Name: sclerostin; targeted mutation 1, Chris Paszty
• MGI ID: MGI:3850014
• Synonyms: Sost^-
• Gene: Sost Location: Chr11:101853284-101857841 bp, - strand Genetic Position: Chr11, 65.48 cM, cytoband D
• Alliance: Sost^tm1Paz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:150166
• Parent Cell Line: GS1 (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The open reading frame was replaced with a neo cassette. The absence of transcript expression was confirmed by northern blot analysis on femur extracts. (J:150166)

Disease models

Expression

In Mice Carrying this Mutation:	108 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sost Mutation: 35 strains or lines available

References

• Original: J:150166 Li X, et al., Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength. J Bone Miner Res. 2008 Jun;23(6):860-9
• All: 11 reference(s)