Baz1b^tm1Ska
Targeted Allele Detail

Summary

• Symbol: Baz1b^tm1Ska
• Name: bromodomain adjacent to zinc finger domain, 1B; targeted mutation 1, Shigeaki Kato
• MGI ID: MGI:3850079
• Synonyms: WSTF^-
• Gene: Baz1b Location: Chr5:135216118-135274983 bp, + strand Genetic Position: Chr5, 75.05 cM
• Alliance: Baz1b^tm1Ska page

Cardiac defects and aortic arch disorganization in Baz1b^tm1Ska/Baz1b⁺ and Baz1b^tm1Ska/Baz1b^tm1Ska embryos

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:149990
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Exon 1 was replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on E10.5 embryo extracts. (J:149990)

Generation of the Baz1b^tm1Ska allele

Disease models

Expression

In Mice Carrying this Mutation:	65 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Baz1b Mutation: 79 strains or lines available

References

• Original: J:149990 Yoshimura K, et al., Distinct function of 2 chromatin remodeling complexes that share a common subunit, Williams syndrome transcription factor (WSTF). Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9280-5
• All: 1 reference(s)