Rictor^tm1.1Mnh
Targeted Allele Detail

Summary

• Symbol: Rictor^tm1.1Mnh
• Name: RPTOR independent companion of MTOR, complex 2; targeted mutation 1.1, Michael N Hall
• MGI ID: MGI:3850086
• Synonyms: rictor^fl
• Gene: Rictor Location: Chr15:6737860-6829882 bp, + strand Genetic Position: Chr15, 3.25 cM, cytoband A1
• Alliance: Rictor^tm1.1Mnh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:150064
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A Frt-flanked neomycin cassette and a loxP site were inserted upstream of exon 4 with an additional loxP site inserted downstream of exon 5. Founder mice were crossed with Flpe transgenic mice to remove the neo cassette leaving exons 4-5 floxed. Gene expression was unaffected as determined by immunoblot analysis of adipose tissue. (J:150064)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rictor Mutation: 141 strains or lines available

References

• Original: J:150064 Cybulski N, et al., mTOR complex 2 in adipose tissue negatively controls whole-body growth. Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9902-7
• All: 16 reference(s)