Sun2^tm1Mhan
Targeted Allele Detail

Summary

• Symbol: Sun2^tm1Mhan
• Name: Sad1 and UNC84 domain containing 2; targeted mutation 1, Min Han
• MGI ID: MGI:3850087
• Synonyms: Sun2^-
• Gene: Sun2 Location: Chr15:79608271-79626737 bp, - strand Genetic Position: Chr15, 37.85 cM
• Alliance: Sun2^tm1Mhan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:150047
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 11 through 16 were replaced with a neo cassette. The absence of protein expression was confirmed by immunohistochemistry on muscle fiber samples. (J:150047)

Expression

In Mice Carrying this Mutation:

27 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sun2 Mutation: 43 strains or lines available

References

• Original: J:150047 Lei K, et al., SUN1 and SUN2 play critical but partially redundant roles in anchoring nuclei in skeletal muscle cells in mice. Proc Natl Acad Sci U S A. 2009 Jun 23;106(25):10207-12
• All: 12 reference(s)