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Tg(Myh6-BRUNOL4*)10Coop
Transgene Detail
Summary
Symbol: Tg(Myh6-BRUNOL4*)10Coop
Name: transgene insertion 10, Thomas A Cooper
MGI ID: MGI:3850088
Synonyms: MHC-CELFdelta, MHC-CELFdelta-10
Transgene: Tg(Myh6-BRUNOL4*)10Coop  Location: unknown  
Alliance: Tg(Myh6-BRUNOL4*)10Coop page
Transgene
origin
Strain of Origin:  FVB
Transgene
description
Transgene Type:    Transgenic (Dominant negative, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Myh6-BRUNOL4*)10Coop expresses 1 gene
 
Mutation detailsA truncated form of the human CELF4 (BRUNOL4), which acts as a dominant negative protein in cultured cells, was expressed in the heart under the control of an alpha-myosin heavy chain promoter. In addition to line 10, lines 11 and 574 were also generated. Line 11 was susequently lost. (J:99369)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 6 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:99369 Ladd AN, et al., Cardiac Tissue-Specific Repression of CELF Activity Disrupts Alternative Splicing and Causes Cardiomyopathy. Mol Cell Biol. 2005 Jul;25(14):6267-78
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory