Efnb1^tm2.2Sor
Targeted Allele Detail

Summary

• Symbol: Efnb1^tm2.2Sor
• Name: ephrin B1; targeted mutation 2.2, Philippe Soriano
• MGI ID: MGI:3850114
• Synonyms: Ephrin-B1^6F
• Gene: Efnb1 Location: ChrX:98179736-98192597 bp, + strand Genetic Position: ChrX, 43.22 cM, cytoband D
• Alliance: Efnb1^tm2.2Sor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:150043
• Parent Cell Line: AK7.1 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Germ line, cre mediated recombination removed the wild-type exon 5 allowing for expression of the modified exon 5 in which all 6 intracellular tyrosines are replaced with phenylalanine. The protein product is predicted to lack the capacity for intracellular signalling. (J:150043)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Efnb1 Mutation: 15 strains or lines available

References

• Original: J:150043 Bush JO, et al., Ephrin-B1 regulates axon guidance by reverse signaling through a PDZ-dependent mechanism. Genes Dev. 2009 Jul 1;23(13):1586-99
• All: 2 reference(s)