Smad9^tm3Jfm
Targeted Allele Detail

Summary

• Symbol: Smad9^tm3Jfm
• Name: SMAD family member 9; targeted mutation 3, James F Martin
• MGI ID: MGI:3850120
• Synonyms: Smad8^lacZ
• Gene: Smad9 Location: Chr3:54663003-54708678 bp, + strand Genetic Position: Chr3, 25.62 cM, cytoband D
• Alliance: Smad9^tm3Jfm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:150213
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An IRES-lacZ and floxed pgk-neo cassette was inserted into exon 4 via homologous recombination. Immunostaining analysis confirmed the absence of endogenous protein and presence of LacZ expression in prostates from homozygous mice. (J:150213)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Smad9 Mutation: 32 strains or lines available

References

• Original: J:150213 Huang Z, et al., Defective pulmonary vascular remodeling in Smad8 mutant mice. Hum Mol Genet. 2009 Aug 1;18(15):2791-801
• All: 1 reference(s)