Clrn1^tm1.1Kuna
Targeted Allele Detail

Summary

• Symbol: Clrn1^tm1.1Kuna
• Name: clarin 1; targeted mutation 1.1, Kumar N Alagramam
• MGI ID: MGI:3850171
• Gene: Clrn1 Location: Chr3:58751449-58792633 bp, - strand Genetic Position: Chr3, 28.78 cM
• Alliance: Clrn1^tm1.1Kuna page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:150215
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Germ line, cre mediated recombination removes the neo cassette and exon 1. RT-PCR on P30 and P60 cochlear extracts confirmed the absence of transcript expression. (J:150215)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Clrn1 Mutation: 17 strains or lines available

References

• Original: J:150215 Geng R, et al., Usher syndrome IIIA gene clarin-1 is essential for hair cell function and associated neural activation. Hum Mol Genet. 2009 Aug 1;18(15):2748-60
• All: 10 reference(s)