Dicer1^tm1.1Mnn
Targeted Allele Detail

Summary

• Symbol: Dicer1^tm1.1Mnn
• Name: dicer 1, ribonuclease type III; targeted mutation 1.1, Jeff Mann
• MGI ID: MGI:3850191
• Synonyms: Dicer1^c
• Gene: Dicer1 Location: Chr12:104654001-104718211 bp, - strand Genetic Position: Chr12, 54.83 cM, cytoband E-F1
• Alliance: Dicer1^tm1.1Mnn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:150221
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S1/SvImJ

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 25 and an frt flanked neo cassette with a 5' loxP site was inserted downstream of exon 27. Germ line, flp mediated recombination removed the neo cassette leaving exons 25 through 27 floxed. (J:150221)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dicer1 Mutation: 96 strains or lines available

References

• Original: J:150221 Mattiske DM, et al., Meiotic maturation failure induced by DICER1 deficiency is derived from primary oocyte ooplasm. Reproduction. 2009 Apr;137(4):625-32
• All: 3 reference(s)