Slfn2^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Slfn2^m1Btlr
• Name: schlafen 2; mutation 1, Bruce Beutler
• MGI ID: MGI:3850348
• Synonyms: elektra, Slfn2^eka
• Gene: Slfn2 Location: Chr11:82955938-82961504 bp, + strand Genetic Position: Chr11, 50.3 cM
• Alliance: Slfn2^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: This mutation comprises a T to A transversion at nucleotide position 586 of the gene (Genbank Accession NM_011408) that results in replacement of isoleucine by asparagine at amino acid position 135 of the protein (I135N). (J:158985)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Slfn2 Mutation: 14 strains or lines available

References

• Original: J:158985 Berger M, et al., An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence. Nat Immunol. 2010 Apr;11(4):335-43
• All: 4 reference(s)