Kdr^tm2Sato
Targeted Allele Detail

Summary

• Symbol: Kdr^tm2Sato
• Name: kinase insert domain protein receptor; targeted mutation 2, Thomas N Sato
• MGI ID: MGI:3850417
• Synonyms: Kdr^fl, VEGFR2^e3loxP, VEGFR2^loxP
• Gene: Kdr Location: Chr5:76093487-76139118 bp, - strand Genetic Position: Chr5, 40.23 cM
• Alliance: Kdr^tm2Sato page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:149917
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3 and an frt flanked pgk-neo cassette followed by a loxP site were inserted downstream of exon 3 via homologous recombination. (J:149917)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kdr Mutation: 74 strains or lines available

References

• Original: J:149917 Hooper AT, et al., Engraftment and reconstitution of hematopoiesis is dependent on VEGFR2-mediated regeneration of sinusoidal endothelial cells. Cell Stem Cell. 2009 Mar 6;4(3):263-74
• All: 37 reference(s)